PTGS2
Prostaglandin G/H synthase 2
UniProt P35354AlphaFold AF-P35354-F1Gene ID 5743
Annotations
- ChEMBL class
- Enzyme > Oxidoreductase
- UniProt family
- Prostaglandin G/H synthase family
- HGNC groups
- Prostaglandin-endoperoxide synthase family
- Synonyms
- COX2
- Ensembl
- ENSG00000073756
- HGNC
- HGNC:9605
- UniProt entry
- PGH2_HUMAN
- Model
- 604 aa · mean pLDDT 93.0 · membrane · 35 P2Rank pockets, top 5 docked
- Docked
- 2,556 compounds · 1,780 highest-affinity poses PoseBusters-valid · 512 not checked (PoseBusters not run) · 64 known in ChEMBL
Associated diseases (Open Targets): rheumatoid arthritis, osteoarthritis, gout +7
- rheumatoid arthritis0.63
- osteoarthritis0.63
- gout0.63
- migraine disorder0.63
- ulcerative colitis0.62
- Headache0.61
- stroke disorder0.61
- myocardial infarction0.61
- arthritic joint disease0.61
- Dysmenorrhea0.61
View all associations on Open Targets
Open Targets Platform 26.09 · overall association score (direct)
Structure
Compounds
How to read the scores
- Vina scores are docking scores in kcal/mol, not measured affinities. More negative is better.
- Large ligands get better scores almost everywhere. Compare a drug with other drugs on the same protein (rank), and a protein with other proteins for the same drug.
- PoseBusters checked only the highest-affinity pose of each pair. A timeout or a PoseBusters error means not checked, not failed.
- No ChEMBL evidence does not mean no binding; most pairs were never tested.
- Some salt entries were docked as their counter-ion, a solvent or a product component, not as the drug. Their rows say what was docked and keep their scores and poses; the desalted form of such a salt (<catalogue number>-desalted) is listed on the drug's page.
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