EGFR
Epidermal growth factor receptor
UniProt P00533AlphaFold AF-P00533-F1Gene ID 1956
Annotations
- ChEMBL class
- Enzyme > Kinase > Protein Kinase > TK protein kinase group > Tyrosine protein kinase EGFR family
- UniProt family
- Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
- HGNC groups
- Erb-b2 receptor tyrosine kinases
- Synonyms
- ERBB, ERBB1, ERRP, HER1
- Ensembl
- ENSG00000146648
- HGNC
- HGNC:3236
- UniProt entry
- EGFR_HUMAN
- Model
- 1,210 aa · mean pLDDT 75.9 · membrane · 57 P2Rank pockets, top 5 docked
- Docked
- 2,554 compounds · 1,822 highest-affinity poses PoseBusters-valid · 512 not checked (PoseBusters not run) · 41 known in ChEMBL
Associated diseases (Open Targets): non-small cell lung carcinoma, lung adenocarcinoma, cancer +7
- non-small cell lung carcinoma0.85
- lung adenocarcinoma0.78
- cancer0.74
- head and neck squamous cell carcinoma0.72
- lung cancer0.72
- breast cancer0.68
- colorectal adenocarcinoma0.68
- glioblastoma0.67
- neoplasm0.65
- inflammatory skin and bowel disease, neonatal, 20.64
View all associations on Open Targets
Open Targets Platform 26.09 · overall association score (direct)
Structure
Compounds
How to read the scores
- Vina scores are docking scores in kcal/mol, not measured affinities. More negative is better.
- Large ligands get better scores almost everywhere. Compare a drug with other drugs on the same protein (rank), and a protein with other proteins for the same drug.
- PoseBusters checked only the highest-affinity pose of each pair. A timeout or a PoseBusters error means not checked, not failed.
- No ChEMBL evidence does not mean no binding; most pairs were never tested.
- Some salt entries were docked as their counter-ion, a solvent or a product component, not as the drug. Their rows say what was docked and keep their scores and poses; the desalted form of such a salt (<catalogue number>-desalted) is listed on the drug's page.
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